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Below is the 2012 NFL schedule for the Lions
| WK | DATE | OPPONENT | TIME (ET) |
| 1 | Sun, Sep 9 | St. Louis | 1:00 PM |
| 2 | Sun, Sep 16 | at San Francisco | 8:20 PM |
| 3 | Sun, Sep 23 | at Tennessee | 1:00 PM |
| 4 | Sun, Sep 30 | Minnesota | 1:00 PM |
| 6 | Sun, Oct 14 | at Philadelphia | 1:00 PM |
| 7 | Mon, Oct 22 | at Chicago | 8:30 PM |
| 8 | Sun, Oct 28 | Seattle | 1:00 PM |
| 9 | Sun, Nov 4 | at Jacksonville | 1:00 PM |
| 10 | Sun, Nov 11 | at Minnesota | 1:00 PM |
| 11 | Sun, Nov 18 | Green Bay | 1:00 PM |
| 12 | Thu, Nov 22 | Houston | 12:30 PM |
| 13 | Sun, Dec 2 | Indianapolis | 1:00 PM |
| 14 | Sun, Dec 9 | at Green Bay | 8:20 PM |
| 15 | Sun, Dec 16 | at Arizona | 4:05 PM |
| 16 | Sat, Dec 22 | Atlanta | 8:30 PM |
| 17 | Sun, Dec 30 | Chicago | 1:00 PM |
