The 2012 odds for the Jacksonville Jaguars will be updated soon. Below is the 2012 Jacksonville Jaguars schedule.
| WK | DATE | OPPONENT | TIME (ET) |
| 1 | Sun, Sep 9 | at Minnesota | 1:00 PM |
| 2 | Sun, Sep 16 | Houston | 1:00 PM |
| 3 | Sun, Sep 23 | at Indianapolis | 1:00 PM |
| 4 | Sun, Sep 30 | Cincinnati | 4:05 PM |
| 5 | Sun, Oct 7 | Chicago | 4:05 PM |
| 7 | Sun, Oct 21 | at Oakland | 4:15 PM |
| 8 | Sun, Oct 28 | at Green Bay | 1:00 PM |
| 9 | Sun, Nov 4 | Detroit | 1:00 PM |
| 10 | Thu, Nov 8 | Indianapolis | 8:20 PM |
| 11 | Sun, Nov 18 | at Houston | 1:00 PM |
| 12 | Sun, Nov 25 | Tennessee | 1:00 PM |
| 13 | Sun, Dec 2 | at Buffalo | 1:00 PM |
| 14 | Sun, Dec 9 | NY Jets | 1:00 PM |
| 15 | Sun, Dec 16 | at Miami | 1:00 PM |
| 16 | Sun, Dec 23 | New England | 1:00 PM |
| 17 | Sun, Dec 30 | at Tennessee | 1:00 PM |
